Aspirin, alone, induced chromosome aberrations in cultured human fibroblasts. Mutagenicity checks of dipyridamole by yourself with bacterial and mammalian cell techniques have been negative.

In clients with renal insufficiency or in situations of everyday living-threatening intoxication, dialysis is usually needed to deal with salicylic overdose; however, considering that dipyridamole is highly protein bound, dialysis is unlikely to eliminate dipyridamole. Exchange transfusion may be indicated in infants and youthful small children.

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AGGRENOX is contraindicated in individuals with recognised hypersensitivity to any in the item factors.

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Notify patients in regards to the signals and signs of GI side effects and what measures to just take if they take place.

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Salicylate can inhibit renal clearance of methotrexate, bringing about bone marrow toxicity, specifically in the aged or renal impaired.

The concurrent use of aspirin with other NSAIDs may enhance bleeding or cause diminished renal function.

Because of the dose ratio of dipyridamole to aspirin, overdosage of AGGRENOX is probably going to generally be dominated by indications and signs or symptoms of dipyridamole overdose.

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